Is it possible to sustain youth and to be impenetrable?

NADH/NAD+ is avital co-enzyme couple that plays a significant role in energy production/consumption within the cells of living organisms.

It was published in Science by Professor David Sinclair(Harvard Medical School,2017) that NAD+ could underlie some effects of aging and propensity to age-related diseases. These include activating the body’s defenses against aging, deleting senescent cells, and reprogramming cells in vivo. Some researchers have found that NADH is beneficial for patients who are suffering from diabetes, Parkinson’s disease, Alzheimer’s disease, and depression.

In April 4 2020,it was reported in Biorxiv that COVID-19 infection strikingly depress NAD levels. Early preclinical data show that nutritional and pharmacological interventions to enhance NAD-based defenses may boost innate immunity.

Due to its importance, NADH detection has received much attention. A variety of analytical methods have been proposed for NADH sensing, including colorimetry, photo-electrochemistry, enzymatic assay, and high- performance liquid chromatography. Among these methods, electrochemical sensors are likely to offer a highly sensitive and in situ analytical approach for the detection of NADH. Due to their rapid response, straightforward operation, and cost effectiveness electrochemical detection method can be applied to explore the predictors of treatment effect in age-related disease or epidemic disease.

Reference

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• 1.Simple aminophenol-based electrochemical probes for non-enzymatic, dual amperometric detection of NADH and hydrogen peroxide
• 2.Development of Biocompatible Cellulose Microfiber Stabilized Carbon Nanofiber Hydrogel for the Efficient Electrochemical Determination of Nicotinamide Adenine Dinucleotide in Physiological Fluids